… GLPG1250 is a potent and specific GPR84 antagonist6. Both PBI-4050 and GLPG1250 are
… for GPR84 modulators may emerge in the future, such as promoting immune responses in …

… Previous works have established that IFNβ augments anti-tumor immune response and
improve the efficacy of ICB [40, 54]. Taken together, we find it is plausible that the …

… of a broader range of high affinity GPR84 antagonists would be of considerable use in …
of GPR84. In early studies, we noted that these molecules were not active at mouse GPR84. …

… or lifestyle, including diet and associated microbial challenges for the immune system. To
address this hypothesis, GPR84 sequences of more than 200 vertebrate species (ortholog …

… response mediated through GPR84 is in line with our earlier results [20]. The ROS production
profile mediated by GPR84 … 10 , that is, the response was induced rapidly upon agonist …

… the innate immune system, including monocytes, macrophages, and neutrophils in the
periphery and microglia in the central nervous system. (9,10) In physiological conditions, …

… GPR84 is that of being a medium-chain fatty acid (MCFA) receptor. While MCFAs have been
shown to activate GPR84… time” free fatty acid receptor subtypes, GPR84 is not expressed by …

… Although the roles of MDSCs in promoting tumor growth and inhibiting immune response …
that GPR84 was exclusively overexpressed on MDSCs. It was further found that GPR84 was …

… β-arrestin recruiting GPR84 agonist was not … response relied, similar to the response
induced by FPR2 agonists, primarily on the actin cytoskeleton. In summary, we show that GPR84 …

… Consistent with this, an antiserum able to identify pSer 221 /pSer 224 recognized GPR84 …
recognized GPR84 after exposure to 2-HTP and not DL-175. Two distinct GPR84 antagonists …