Gastrointestinal effects of intracerebroventricularly injected nociceptin/orphaninFQ in rats
M Broccardo, R Guerrini, C Petrella, G Improta - Peptides, 2004 - Elsevier
Nociceptin/orphanin FQ/(N/OFQ), a novel heptadecapeptide recently isolated from porcine
and rat brain, is the endogenous ligand of the N/OFQ peptide receptor (NOP, previously
known as ORL-1). In this study we examined the effects of intracerebroventricularly (icv)
injected N/OFQ on gastric emptying, gastrointestinal transit, colonic propulsion and gastric
acid secretion in rats. N/OFQ (0.01–10nmol/rat) significantly delayed gastric emptying of a
phenol red meal, inhibited transit of a non-absorbable charcoal marker through the small …
and rat brain, is the endogenous ligand of the N/OFQ peptide receptor (NOP, previously
known as ORL-1). In this study we examined the effects of intracerebroventricularly (icv)
injected N/OFQ on gastric emptying, gastrointestinal transit, colonic propulsion and gastric
acid secretion in rats. N/OFQ (0.01–10nmol/rat) significantly delayed gastric emptying of a
phenol red meal, inhibited transit of a non-absorbable charcoal marker through the small …
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