Gd (III)-nanodiamond conjugates for MRI contrast enhancement
LM Manus, DJ Mastarone, EA Waters, XQ Zhang… - Nano …, 2010 - ACS Publications
Nano letters, 2010•ACS Publications
A Gd (III)-nanodiamond conjugate [Gd (III)-ND] was prepared and characterized, enabling
detection of nanodiamonds by MR imaging. The Gd (III)-ND particles significantly reduced
the T 1 of water protons with a per-Gd (III) relaxivity of 58.82±1.18 mM− 1 s− 1 at 1.5 T (60
MHz). This represents a 10-fold increase compared to the monomer Gd (III) complex (r 1=
5.42±0.20 mM− 1 s− 1) and is among the highest per-Gd (III) relaxivities reported.
detection of nanodiamonds by MR imaging. The Gd (III)-ND particles significantly reduced
the T 1 of water protons with a per-Gd (III) relaxivity of 58.82±1.18 mM− 1 s− 1 at 1.5 T (60
MHz). This represents a 10-fold increase compared to the monomer Gd (III) complex (r 1=
5.42±0.20 mM− 1 s− 1) and is among the highest per-Gd (III) relaxivities reported.
A Gd(III)-nanodiamond conjugate [Gd(III)-ND] was prepared and characterized, enabling detection of nanodiamonds by MR imaging. The Gd(III)-ND particles significantly reduced the T1 of water protons with a per-Gd(III) relaxivity of 58.82 ± 1.18 mM−1 s−1 at 1.5 T (60 MHz). This represents a 10-fold increase compared to the monomer Gd(III) complex (r1 = 5.42 ± 0.20 mM−1 s−1) and is among the highest per-Gd(III) relaxivities reported.
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