Animal studies show significant differences in steroid metabolism between male and female
subjects. Similar studies in human subjects are still needed. The aim of this study was to
evaluate differences in 24-h urinary excretion of cortisol and androgen metabolites between
healthy male and female volunteers to estimate if such differences were significant. Urinary
metabolite measurements were performed by gas chromatography. The median urinary
excretion of total cortisol metabolites was 6965 μ g/day for men and 4595 μ g/day for women …

This is a comment on" Gender differences in the urinary excretion rates of cortisol and
androgen metabolites." Ann Clin Biochem. 2000 Nov; 37 (Pt 6): 770-4. This is a comment
on" Origins of the sex difference in human urinary free cortisol excretion." Ann Clin Biochem.
1997 May; 34 (Pt 3): 326. This is a comment on" Urine-free cortisol excretion: evidence of
sex-dependence." Ann Clin Biochem. 1994 Sep; 31 (Pt 5): 455-8.