Gene expression in skeletal muscle after an acute intravenous GH bolus in human subjects: identification of a mechanism regulating ANGPTL4
BFF Clasen, T Krusenstjerna-Hafstr… - Journal of Lipid …, 2013 - ASBMB
Growth hormone (GH) acutely stimulates lipolysis and fat oxidation, a process that operates
postabsorptively and involves activation of the JAK-STAT pathway in the target tissue; no in
vivo data exist regarding subsequent GH-regulated gene transcription. We obtained serum
samples and muscle biopsies in human subjects before and 2 h after administration of a GH
bolus. A significant (∼ 75%) elevation in serum FFA levels was recorded post GH.
Microarray identified 79 GH-regulated genes in muscle. With qRT-PCR, we then examined …
postabsorptively and involves activation of the JAK-STAT pathway in the target tissue; no in
vivo data exist regarding subsequent GH-regulated gene transcription. We obtained serum
samples and muscle biopsies in human subjects before and 2 h after administration of a GH
bolus. A significant (∼ 75%) elevation in serum FFA levels was recorded post GH.
Microarray identified 79 GH-regulated genes in muscle. With qRT-PCR, we then examined …
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