Generating aptamers by cell-SELEX for applications in molecular medicine
M Ye, J Hu, M Peng, J Liu, J Liu, H Liu, X Zhao… - International journal of …, 2012 - mdpi.com
Aptamers are single-stranded oligonucleotides of DNA or RNA that bind to target molecules
with high affinity and specificity. Typically, aptamers are generated by an iterative selection
process, called systematic evolution of ligands by exponential enrichment (SELEX). Recent
advancements in SELEX technology have extended aptamer selection from comparatively
simple mixtures of purified proteins to whole living cells, and now cell-based SELEX (or cell-
SELEX) can isolate aptamers that bind to specific target cells. Combined with …
with high affinity and specificity. Typically, aptamers are generated by an iterative selection
process, called systematic evolution of ligands by exponential enrichment (SELEX). Recent
advancements in SELEX technology have extended aptamer selection from comparatively
simple mixtures of purified proteins to whole living cells, and now cell-based SELEX (or cell-
SELEX) can isolate aptamers that bind to specific target cells. Combined with …
[引用][C] Generating Aptamers by Cell-SELEX for Applications in Molecular Medicine
H Liu, X Zhao, W Tan, J Liu, M Peng, J Liu, J Hu, M Ye - 2012
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