Genetic analyses of early-onset Alzheimer's disease using next generation sequencing
Alzheimer's disease (AD) is the most common type of neurodegenerative dementia, but the
cause of AD remained poorly understood. Many mutations in the amyloid precursor protein
(APP) and presenilin 1 and 2 (PSEN1 and PSEN2) have been reported as the pathogenic
causes of early-onset AD (EOAD), which accounts for up to 5% of all AD cases. In this study,
we screened familiar/de novo EOAD (n= 67) samples by next-generation sequencing (NGS)
of a 50-gene panel, which included causative and possible pathogenic variants linked to …
cause of AD remained poorly understood. Many mutations in the amyloid precursor protein
(APP) and presenilin 1 and 2 (PSEN1 and PSEN2) have been reported as the pathogenic
causes of early-onset AD (EOAD), which accounts for up to 5% of all AD cases. In this study,
we screened familiar/de novo EOAD (n= 67) samples by next-generation sequencing (NGS)
of a 50-gene panel, which included causative and possible pathogenic variants linked to …
Genetic analyses of early-onset Alzheimer's disease using next generation sequencing.
VVG Vo Van Giau, E Bagyinszky… - 2019 - cabidigitallibrary.org
Alzheimer's disease (AD) is the most common type of neurodegenerative dementia, but the
cause of AD remained poorly understood. Many mutations in the amyloid precursor protein
(APP) and presenilin 1 and 2 (PSEN1 and PSEN2) have been reported as the pathogenic
causes of early-onset AD (EOAD), which accounts for up to 5% of all AD cases. In this study,
we screened familiar/de novo EOAD (n= 67) samples by next-generation sequencing (NGS)
of a 50-gene panel, which included causative and possible pathogenic variants linked to …
cause of AD remained poorly understood. Many mutations in the amyloid precursor protein
(APP) and presenilin 1 and 2 (PSEN1 and PSEN2) have been reported as the pathogenic
causes of early-onset AD (EOAD), which accounts for up to 5% of all AD cases. In this study,
we screened familiar/de novo EOAD (n= 67) samples by next-generation sequencing (NGS)
of a 50-gene panel, which included causative and possible pathogenic variants linked to …
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