… test results for genetic effects. To search for sequence variants that associate with PSA levels,
… study and follow-up analysis using PSA information from 15,757 Icelandic and 454 British …

… The goal of genetically correcting PSA levels … variants to a man’s inherent PSA level. We
showed that a straightforward calculation of genetically adjusted, personalized PSA levels using …

… few suggestively associated sequence variants have been … present study was corrected for
multiple testing using a weighted … adjusted and standardized PSA values for each individual. …

… benefit to adding 33 prostate cancer-associated SNPs to PSA level 25, while another study
reported that four genetic variants can be useful in correcting PSA, leading to a reduction in …

… We demonstrate that genetically correcting PSA for the combined genetic effect of four … The
genetic correction of each individual man’s PSA level did not improve discrimination between …

… effect of genetic correction of measured serum PSA results using the 4 … values, controls
carried a median of 4 PSA-SNP alleles. We next genetically corrected the measured PSA values …

… six genetic loci that were significantly associated with PSA level… genetic variants that are
associated with serum level of PSA … biomarker cutoff values after applying a genetic correction to …

… 85 000 men from the Prostate Testing for Cancer and Treatment (… Original PSA values
from the ProtecT study and PSA … show that 1 of the 30 sequence variants we detected (rs7252245) …

… associated with PSA level. Independent case and control analyses indicated that factors
associated with PSA … Univariate analyses showed a significant age and PSA correlation among …

… The Prostate Testing for cancer and Treatment study (ProtecT… that if the genetic marker is
associated with PSA level and not … using the low PSA controls and close to the null when using …