Decorin and biglycan are class I small leucine-rich proteoglycans (SLRPs) involved in
regulation of collagen fibril and matrix assembly. We hypothesize that tissue-specific matrix
assembly, such as in the cornea, requires a coordinate regulation involving multiple SLRPs.
To this end, we investigated the expression of decorin and biglycan in the cornea of mice
deficient in either SLRP gene and in double-mutant mice. Decorin and biglycan exhibited
overlapping spatial expression patterns throughout the corneal stroma with differential …