Genetic features of MCR-1-producing colistin-resistant Escherichia coli isolates in South Africa
Antimicrobial agents and chemotherapy, 2016•Am Soc Microbiol
ABSTRACT A series of colistin-resistant Escherichia coli clinical isolates was recovered from
hospitalized and community patients in South Africa. Seven clonally unrelated isolates
harbored the mcr-1 gene located on different plasmid backbones. Two distinct plasmids
were fully sequenced, and identical 2,600-bp-long DNA sequences defining a mcr-1
cassette were identified. Promoter sequences responsible for the expression of mcr-1,
deduced from the precise identification of the+ 1 transcription start site for mcr-1, were …
hospitalized and community patients in South Africa. Seven clonally unrelated isolates
harbored the mcr-1 gene located on different plasmid backbones. Two distinct plasmids
were fully sequenced, and identical 2,600-bp-long DNA sequences defining a mcr-1
cassette were identified. Promoter sequences responsible for the expression of mcr-1,
deduced from the precise identification of the+ 1 transcription start site for mcr-1, were …
Abstract
A series of colistin-resistant Escherichia coli clinical isolates was recovered from hospitalized and community patients in South Africa. Seven clonally unrelated isolates harbored the mcr-1 gene located on different plasmid backbones. Two distinct plasmids were fully sequenced, and identical 2,600-bp-long DNA sequences defining a mcr-1 cassette were identified. Promoter sequences responsible for the expression of mcr-1, deduced from the precise identification of the +1 transcription start site for mcr-1, were characterized.
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