Genome‐wide association studies of exacerbations in children using long‐acting beta2‐agonists
EMA Slob, LB Richards, SJH Vijverberg… - Pediatric Allergy and …, 2021 - Wiley Online Library
Background Some children with asthma experience exacerbations despite long‐acting
beta2‐agonist (LABA) treatment. While this variability is partly caused by genetic variation,
no genome‐wide study until now has investigated which genetic factors associated with risk
of exacerbations despite LABA use in children with asthma. We aimed to assess whether
genetic variation was associated with exacerbations in children treated with LABA from a
global consortium. Methods A meta‐analysis of genome‐wide association studies (meta …
beta2‐agonist (LABA) treatment. While this variability is partly caused by genetic variation,
no genome‐wide study until now has investigated which genetic factors associated with risk
of exacerbations despite LABA use in children with asthma. We aimed to assess whether
genetic variation was associated with exacerbations in children treated with LABA from a
global consortium. Methods A meta‐analysis of genome‐wide association studies (meta …
[PDF][PDF] Genome-wide association studies of exacerbations in children using long-acting beta2-agonists
LB Richards, EMA Slob, SJH Vijverberg… - … discovery and treatable …, 2021 - pure.uva.nl
Abstract Background: Somechildrenwithasthmaexperienceexacer…-acting beta2-agonist
(LABA) treatment. While this variability is partly caused by genetic variation, no genome-
wide study until now has investigated which genetic factors associatewithriskofexacerbationsdespiteLA…
. Weaimedto assess whether genetic variation was associated with exacerbations in
children treated with LABA from a global consortium. Methods: A meta-analysis of genome-
wide association studies (meta-GWAS) was performed in 1,425 children and young adults …
(LABA) treatment. While this variability is partly caused by genetic variation, no genome-
wide study until now has investigated which genetic factors associatewithriskofexacerbationsdespiteLA…
. Weaimedto assess whether genetic variation was associated with exacerbations in
children treated with LABA from a global consortium. Methods: A meta-analysis of genome-
wide association studies (meta-GWAS) was performed in 1,425 children and young adults …