Genome-wide CRISPR screens define determinants of epithelial-mesenchymal transition mediated immune evasion by pancreatic cancer cells
The genetic circuits that allow cancer cells to evade immune killing via epithelial
mesenchymal plasticity remain poorly understood. Here, we showed that mesenchymal-like
(Mes) KPC3 pancreatic cancer cells were more resistant to cytotoxic T lymphocyte (CTL)–
mediated killing than the parental epithelial–like (Epi) cells and used parallel genome-wide
CRISPR screens to assess the molecular underpinnings of this difference. Core CTL-
evasion genes (such as IFN-γ pathway components) were clearly evident in both types …
mesenchymal plasticity remain poorly understood. Here, we showed that mesenchymal-like
(Mes) KPC3 pancreatic cancer cells were more resistant to cytotoxic T lymphocyte (CTL)–
mediated killing than the parental epithelial–like (Epi) cells and used parallel genome-wide
CRISPR screens to assess the molecular underpinnings of this difference. Core CTL-
evasion genes (such as IFN-γ pathway components) were clearly evident in both types …
Genome-wide CRISPR screens define determinants of epithelial-mesenchymal transition mediated immune evasion by pancreatic cancer cells
L Rotteveel, AJ Poot… - EJNMMI …, 2023 - scholarlypublications …
The genetic circuits that allow cancer cells to evade immune killing via epithelial
mesenchymal plasticity remain poorly understood. Here, we showed that mesenchymal-like
(Mes) KPC3 pancreatic cancer cells were more resistant to cytotoxic T lymphocyte (CTL)–
mediated killing than the parental epithelial–like (Epi) cells and used parallel genome-wide
CRISPR screens to assess the molecular underpinnings of this difference. Core CTL-
evasion genes (such as IFN-γ pathway components) were clearly evident in both types …
mesenchymal plasticity remain poorly understood. Here, we showed that mesenchymal-like
(Mes) KPC3 pancreatic cancer cells were more resistant to cytotoxic T lymphocyte (CTL)–
mediated killing than the parental epithelial–like (Epi) cells and used parallel genome-wide
CRISPR screens to assess the molecular underpinnings of this difference. Core CTL-
evasion genes (such as IFN-γ pathway components) were clearly evident in both types …
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