Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels
Vitamin D is a steroid hormone precursor that is associated with a range of human traits and
diseases. Previous GWAS of serum 25-hydroxyvitamin D concentrations have identified four
genome-wide significant loci (GC, NADSYN1/DHCR7, CYP2R1, CYP24A1). In this study, we
expand the previous SUNLIGHT Consortium GWAS discovery sample size from 16,125 to
79,366 (all European descent). This larger GWAS yields two additional loci harboring
genome-wide significant variants (P= 4.7× 10− 9 at rs8018720 in SEC23A, and P= 1.9× 10 …
diseases. Previous GWAS of serum 25-hydroxyvitamin D concentrations have identified four
genome-wide significant loci (GC, NADSYN1/DHCR7, CYP2R1, CYP24A1). In this study, we
expand the previous SUNLIGHT Consortium GWAS discovery sample size from 16,125 to
79,366 (all European descent). This larger GWAS yields two additional loci harboring
genome-wide significant variants (P= 4.7× 10− 9 at rs8018720 in SEC23A, and P= 1.9× 10 …
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