Genome-wide association study of lung function decline in adults with and without asthma
M Imboden, E Bouzigon, I Curjuric, A Ramasamy… - Journal of allergy and …, 2012 - Elsevier
BACKGROUND: Genome-wide association studies have identified determinants of chronic
obstructive pulmonary disease, asthma, and lung function level; however, none have
addressed decline in lung function. OBJECTIVE: We conducted the first genome-wide
association study on the age-related decrease in FEV1 and its ratio to forced vital capacity
(FVC) stratified a priori by asthma status. METHODS: Discovery cohorts included adults of
European ancestry (1,441 asthmatic and 2,677 nonasthmatic participants: the …
obstructive pulmonary disease, asthma, and lung function level; however, none have
addressed decline in lung function. OBJECTIVE: We conducted the first genome-wide
association study on the age-related decrease in FEV1 and its ratio to forced vital capacity
(FVC) stratified a priori by asthma status. METHODS: Discovery cohorts included adults of
European ancestry (1,441 asthmatic and 2,677 nonasthmatic participants: the …
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