[HTML][HTML] Genotypes and haplotypes in the AXIN2 and TCF7L2 genes are associated with susceptibility and with clinicopathological characteristics in breast cancer …
MA Rosales-Reynoso… - British Journal of …, 2022 - frontierspartnerships.org
MA Rosales-Reynoso, V Rosas-Enríquez, AM Saucedo-Sariñana, M Pérez-Coria…
British Journal of Biomedical Science, 2022•frontierspartnerships.orgBackground. Breast cancer is a multifactorial disease whose genetic susceptibility is related
to polymorphic variants of cell proliferation and migration pathways. Variants in AXIN2 and
TCF7L2 in the Wnt-β catenin pathway have been associated with different types of cancer;
however, little is known about its role in breast cancer. This study tests the hypothesis of
links between AXIN2 rs1133683 and rs2240308, and TCF7L2 rs7903146 and rs12255372
variants in breast cancer. Methods. Peripheral blood samples were obtained from 404 …
to polymorphic variants of cell proliferation and migration pathways. Variants in AXIN2 and
TCF7L2 in the Wnt-β catenin pathway have been associated with different types of cancer;
however, little is known about its role in breast cancer. This study tests the hypothesis of
links between AXIN2 rs1133683 and rs2240308, and TCF7L2 rs7903146 and rs12255372
variants in breast cancer. Methods. Peripheral blood samples were obtained from 404 …
Background
Breast cancer is a multifactorial disease whose genetic susceptibility is related to polymorphic variants of cell proliferation and migration pathways. Variants in AXIN2 and TCF7L2 in the Wnt-β catenin pathway have been associated with different types of cancer; however, little is known about its role in breast cancer. This study tests the hypothesis of links between AXIN2 rs1133683 and rs2240308, and TCF7L2 rs7903146 and rs12255372 variants in breast cancer.
Methods
Peripheral blood samples were obtained from 404 women (202 patients and 202 control females). The polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) methodology was used to identify the gene variants.
Results
The AXIN2 rs2240308 (C>T), and TCF7L2 rs7903146 (C>T) and rs12255372 (G>T) variants were associated with breast cancer and with age, TNM stage, and histologic-molecular subtype (p= 0.001). Likewise, the haplotype T-T in the TCF7L2 gene (rs7903146-rs12253372) was significantly related with breast cancer (OR= 2.66, 95%, CI= 1.64-4.30, p= 0.001).
Conclusion
Our data show a link between AXIN2 rs2240308 and TCF7L2 rs7903146 and rs12255372 variants in breast cancer, and speculate this may be important in pathogenesis.
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