Ginsenosides act as positive modulators of P2X4 receptors
We investigated the selectivity of protopanaxadiol ginsenosides from Panax ginseng acting
as positive allosteric modulators on P2X receptors. ATP-induced responses were measured
in stable cell lines overexpressing human P2X4 using a YOPRO-1 dye uptake assay,
intracellular calcium measurements, and whole-cell patch-clamp recordings. Ginsenosides
CK and Rd were demonstrated to enhance ATP responses at P2X4 by∼ twofold, similar to
potentiation by the known positive modulator ivermectin. Investigations into the role of P2X4 …
as positive allosteric modulators on P2X receptors. ATP-induced responses were measured
in stable cell lines overexpressing human P2X4 using a YOPRO-1 dye uptake assay,
intracellular calcium measurements, and whole-cell patch-clamp recordings. Ginsenosides
CK and Rd were demonstrated to enhance ATP responses at P2X4 by∼ twofold, similar to
potentiation by the known positive modulator ivermectin. Investigations into the role of P2X4 …
Ginsenosides act as positive modulators of P2X4 receptors.
KD Kshitija Dhuna, M Felgate, SM Bidula, S Walpole… - 2019 - cabidigitallibrary.org
We investigated the selectivity of protopanaxadiol ginsenosides from Panax ginseng acting
as positive allosteric modulators on P2X receptors. ATP-induced responses were measured
in stable cell lines overexpressing human P2X4 using a YOPRO-1 dye uptake assay,
intracellular calcium measurements, and whole-cell patch-clamp recordings. Ginsenosides
CK and Rd were demonstrated to enhance ATP responses at P2X4 by∼ twofold, similar to
potentiation by the known positive modulator ivermectin. Investigations into the role of P2X4 …
as positive allosteric modulators on P2X receptors. ATP-induced responses were measured
in stable cell lines overexpressing human P2X4 using a YOPRO-1 dye uptake assay,
intracellular calcium measurements, and whole-cell patch-clamp recordings. Ginsenosides
CK and Rd were demonstrated to enhance ATP responses at P2X4 by∼ twofold, similar to
potentiation by the known positive modulator ivermectin. Investigations into the role of P2X4 …
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