[HTML][HTML] Glipizide, an antidiabetic drug, suppresses tumor growth and metastasis by inhibiting angiogenesis
Angiogenesis is involved in the development, progression and metastasis of various human
cancers. Herein, we report the discovery of glipizide, a widely used drug for type 2 diabetes
mellitus, as a promising anticancer agent through the inhibition of tumor angiogenesis. By
high-throughput screening (HTS) of an FDA approved drug library utilizing our in vivo chick
embryo chorioallantoic membrane (CAM) and yolk sac membrane (YSM) models, glipizide
has been identified to significantly inhibit blood vessel formation and development …
cancers. Herein, we report the discovery of glipizide, a widely used drug for type 2 diabetes
mellitus, as a promising anticancer agent through the inhibition of tumor angiogenesis. By
high-throughput screening (HTS) of an FDA approved drug library utilizing our in vivo chick
embryo chorioallantoic membrane (CAM) and yolk sac membrane (YSM) models, glipizide
has been identified to significantly inhibit blood vessel formation and development …