Glitazones differentially regulate primary astrocyte and glioma cell survival: involvement of reactive oxygen species and peroxisome proliferator-activated receptor-γ
JM Pérez-Ortiz, P Tranque, CF Vaquero… - Journal of Biological …, 2004 - ASBMB
The glitazones or thiazolidinediones are ligands of the peroxisome proliferator-activated
receptor γ (PPARγ). The glitazones are used in the treatment of diabetes, regulate
adipogenesis, inflammation, cell proliferation, and induce apoptosis in several cancer cell
types. High grade astrocytomas are rapidly growing tumors derived from astrocytes, for
which new treatments are needed. We determined the effects of two glitazones, ciglitazone
and the therapeutic rosiglitazone, on the survival of serum-deprived primary rat astrocytes …
receptor γ (PPARγ). The glitazones are used in the treatment of diabetes, regulate
adipogenesis, inflammation, cell proliferation, and induce apoptosis in several cancer cell
types. High grade astrocytomas are rapidly growing tumors derived from astrocytes, for
which new treatments are needed. We determined the effects of two glitazones, ciglitazone
and the therapeutic rosiglitazone, on the survival of serum-deprived primary rat astrocytes …
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