Global alterations to the choroid plexus blood-CSF barrier in amyotrophic lateral sclerosis

J Saul, E Hutchins, R Reiman, M Saul… - Acta Neuropathologica …, 2020 - Springer
… The choroid plexus (CP) is a highly vascularized structure located in the ventricles that forms
the blood-CSF barrier (… In addition to its role as a physical barrier, the CP functions in CSF …

Choroid plexus enlargement in amyotrophic lateral sclerosis patients and its correlation with clinical disability and blood-CSF barrier permeability

T Dai, J Lou, D Kong, J Li, Q Ren, Y Chen… - … and Barriers of the CNS, 2024 - Springer
… in ALS patients to date. Thus, we aimed to determine whether in vivo CP enlargement may
occur in ALS … clinical disabilities and blood-CSF barrier (BCSFB) permeability in ALS patients. …

BloodCSF barrier integrity in amyotrophic lateral sclerosis

V Klose, S Jesse, J Lewerenz, J Kassubek, J Dorst… - Brain, 2024 - academic.oup.com
… We conclude that the blood/CSF barrier is intact in this large cohort of ALS patients and that
Global alterations to the choroid plexus blood- 24 CSF barrier in amyotrophic lateral sclerosis

Choroid plexus and the blood–cerebrospinal fluid barrier in disease

P Solár, A Zamani, L Kubíčková, P Dubový… - … and Barriers of the CNS, 2020 - Springer
… diseases (eg, multiple sclerosis). Moreover, the CP was … changes and regulation of the
B-CSF barrier in different diseases. A better understanding of the role played by the B-CSF barrier

[HTML][HTML] Breached barriers: a scoping review of blood-central nervous system barrier pathology in amyotrophic lateral sclerosis

A Mirian, A Moszczynski, S Soleimani… - Frontiers in Cellular …, 2022 - frontiersin.org
changes in the blood-central nervous system barriers (BCNSB) in amyotrophic lateral
sclerosis (ALS). … Lastly, this review did not focus on the BCSFB at the choroid plexus. Given the …

[HTML][HTML] Amyotrophic lateral sclerosis: is the spinal fluid pathway involved in seeding and spread?

R Smith, K Myers, J Ravits, R Bowser - Medical hypotheses, 2015 - Elsevier
… in ALS progression, it follows that the choroid plexus (CP) … distribute molecules both locally
and globally within the brain [… There are a number of changes in both the CSF and the CP …

Molecular anatomy and functions of the choroidal blood-cerebrospinal fluid barrier in health and disease

JF Ghersi-Egea, N Strazielle, M Catala… - Acta …, 2018 - Springer
blood-CSF barrier (BCSFB) per se. Different types of immune cells are associated with the
choroid plexuses… in multiple sclerosis patients [71, 166]. The functional consequences of these …

Choroid plexus–cerebrospinal fluid transport dynamics: support of brain health and a role in neurotherapeutics

CE Johanson - Conn's translational neuroscience, 2017 - Elsevier
… CP epithelial cells at the bloodCSF barrier (BCSFB) carry out … , hormones, and peptides to
CSF for global brain distribution. … the course of amyotrophic lateral sclerosis (ALS). Increasing …

Blood–spinal cord barrier breakdown and pericyte reductions in amyotrophic lateral sclerosis

EA Winkler, JD Sengillo, JS Sullivan, JS Henkel… - Acta …, 2013 - Springer
… The present study further supports the existence of alterations of the BSCB in ALS subjects.
Past studies utilizing both CSF and tissue analyses have suggested possible BBB and/or …

Blood–brain barrier dysfunction and myelin basic protein in survival of amyotrophic lateral sclerosis with or without frontotemporal dementia

JY Li, ZY Cai, XH Sun, DC Shen, XZ Yang, MS Liu… - Neurological …, 2022 - Springer
… BBB in ALS and ALS-FTD patients by documenting changes in … in patients with ALS [6]
focusing on choroid plexus showed … immune component of the choroid plexus found a significant …