Aims To assess the capacity of global longitudinal strain (GLS) in patients with aortic
stenosis (AS) to (i) detect the subclinical left ventricular (LV) dysfunction [LV ejection fraction
(LVEF)≥ 50% patients];(ii) predict all-cause mortality and major adverse cardiac events
(MACE)(all patients), and (iii) provide incremental prognostic information over current risk
markers. Methods and results Patients with AS (n= 146) and age-matched controls (n= 12)
underwent baseline echocardiography to assess AS severity, conventional LV parameters …

Background: Global longitudinal strain (GLS), measured with speckle tracking
echocardiography, is a sensitive marker of LV systolic function, however its prognostic
capacity in patients with aortic stenosis (AS) is uncertain. We hypothesised that in patients
with AS, GLS would predict:(1) All-cause mortality and (2) Major adverse cardiac events
(MACE: death or hospitalisation due to cardiac causes). Methods: Subjects with AS (n= 146)
and controls (n= 10) underwent baseline echocardiography to assess AS severity and GLS …