Global reprogramming of host kinase signaling in response to fungal infection
Cryptococcus neoformans (Cn) is a deadly fungal pathogen whose intracellular lifestyle is
important for virulence. Host mechanisms controlling fungal phagocytosis and replication
remain obscure. Here, we perform a global phosphoproteomic analysis of the host response
to Cryptococcus infection. Our analysis reveals numerous and diverse host proteins that are
differentially phosphorylated following fungal ingestion by macrophages, thereby indicating
global reprogramming of host kinase signaling. Notably, phagocytosis of the pathogen …
important for virulence. Host mechanisms controlling fungal phagocytosis and replication
remain obscure. Here, we perform a global phosphoproteomic analysis of the host response
to Cryptococcus infection. Our analysis reveals numerous and diverse host proteins that are
differentially phosphorylated following fungal ingestion by macrophages, thereby indicating
global reprogramming of host kinase signaling. Notably, phagocytosis of the pathogen …
Global reprogramming of host kinase signaling in response to fungal infection.
AP Aseem Pandey, DSL Ding ShengLi… - 2017 - cabidigitallibrary.org
Cryptococcus neoformans (Cn) is a deadly fungal pathogen whose intracellular lifestyle is
important for virulence. Host mechanisms controlling fungal phagocytosis and replication
remain obscure. Here, we perform a global phosphoproteomic analysis of the host response
to Cryptococcus infection. Our analysis reveals numerous and diverse host proteins that are
differentially phosphorylated following fungal ingestion by macrophages, thereby indicating
global reprogramming of host kinase signaling. Notably, phagocytosis of the pathogen …
important for virulence. Host mechanisms controlling fungal phagocytosis and replication
remain obscure. Here, we perform a global phosphoproteomic analysis of the host response
to Cryptococcus infection. Our analysis reveals numerous and diverse host proteins that are
differentially phosphorylated following fungal ingestion by macrophages, thereby indicating
global reprogramming of host kinase signaling. Notably, phagocytosis of the pathogen …
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