Globular hepatic amyloid is highly sensitive and specific for LECT2 amyloidosis
VS Chandan, SS Shah, DM Lam-Himlin… - The American journal …, 2015 - journals.lww.com
Globular hepatic amyloid (GHA) is rare, and its clinical significance remains unclear.
Recently, leukocyte chemotactic factor–associated amyloidosis (ALECT2) has been
reported to involve the liver, showing a globular pattern. We reviewed 70 consecutive cases
of hepatic amyloidosis to determine the prevalence and morphology of hepatic amyloid
subtypes, especially ALECT2 and its association with GHA. Each case was reviewed for
amyloid subtype (immunohistochemistry and/or mass spectrometry), its pattern (linear or …
Recently, leukocyte chemotactic factor–associated amyloidosis (ALECT2) has been
reported to involve the liver, showing a globular pattern. We reviewed 70 consecutive cases
of hepatic amyloidosis to determine the prevalence and morphology of hepatic amyloid
subtypes, especially ALECT2 and its association with GHA. Each case was reviewed for
amyloid subtype (immunohistochemistry and/or mass spectrometry), its pattern (linear or …
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