Glucagon like peptide-1 receptor expression in the human thyroid gland
B Gier, PC Butler, CK Lai, D Kirakossian… - The Journal of …, 2012 - academic.oup.com
The Journal of Clinical Endocrinology & Metabolism, 2012•academic.oup.com
Background: Glucagon like peptide-1 (GLP-1) mimetic therapy induces medullary thyroid
neoplasia in rodents. We sought to establish whether C cells in human medullary thyroid
carcinoma, C cell hyperplasia, and normal human thyroid express the GLP-1 receptor.
Methods: Thyroid tissue samples with medullary thyroid carcinoma (n= 12), C cell
hyperplasia (n= 9), papillary thyroid carcinoma (n= 17), and normal human thyroid (n= 15)
were evaluated by immunofluorescence for expression of calcitonin and GLP-1 receptors …
neoplasia in rodents. We sought to establish whether C cells in human medullary thyroid
carcinoma, C cell hyperplasia, and normal human thyroid express the GLP-1 receptor.
Methods: Thyroid tissue samples with medullary thyroid carcinoma (n= 12), C cell
hyperplasia (n= 9), papillary thyroid carcinoma (n= 17), and normal human thyroid (n= 15)
were evaluated by immunofluorescence for expression of calcitonin and GLP-1 receptors …
Background
Glucagon like peptide-1 (GLP-1) mimetic therapy induces medullary thyroid neoplasia in rodents. We sought to establish whether C cells in human medullary thyroid carcinoma, C cell hyperplasia, and normal human thyroid express the GLP-1 receptor.
Methods
Thyroid tissue samples with medullary thyroid carcinoma (n = 12), C cell hyperplasia (n = 9), papillary thyroid carcinoma (n = 17), and normal human thyroid (n = 15) were evaluated by immunofluorescence for expression of calcitonin and GLP-1 receptors.
Results
Coincident immunoreactivity for calcitonin and GLP-1 receptor was consistently observed in both medullary thyroid carcinoma and C cell hyperplasia. GLP-1 receptor immunoreactivity was also detected in 18% of papillary thyroid carcinoma (three of 17 cases). Within normal human thyroid tissue, GLP-1 receptor immunoreactivity was found in five of 15 of the examined cases in about 35% of the total C cells assessed.
Conclusions
In humans, neoplastic and hyperplastic lesions of thyroid C cells express the GLP-1 receptor. GLP-1 receptor expression is detected in 18% papillary thyroid carcinomas and in C cells in 33% of control thyroid lobes. The consequence of long-term pharmacologically increased GLP-1 signaling on these GLP-1 receptor-expressing cells in the thyroid gland in humans remains unknown, but appropriately powered prospective studies to exclude an increase in medullary or papillary carcinomas of the thyroid are warranted.
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