… may reduce the immunogenicity of mRNA-based SARS-CoV-2 vaccination, we first compared
participants on or off glucocorticoids with immunocompetent controls. Glucocorticoid use …

… whom were receiving glucocorticoids, B-cell depletion therapy, or … impairing vaccine responses
(14), we examined the … In contrast, immunogenicity seemed substantially lower (60%) in …

… SARS-CoV-2 mRNA vaccines in patients receiving B-cell-depleting drugs. However, …
Glucocorticoids and B cell depleting agents substantially impair immunogenicity of mRNA vaccines …

… substantially reduce the immunogenicity of these vaccines. … The majority of studies
investigated effects on mRNA vaccine … with glucocorticoids, abatacept or B cell-depleting agents. …

… type I IFN production and B cell activation, two mechanisms … titres in SLE patients under
Glucocorticoids’ regimen as a … were significantly lower compared to non-Glucocorticoid users. …

… glucocorticoid dosages (at dosages equivalent to prednisolone ≥10 mg).1 6 7 Additionally,
B cell depleting drugs… IgA serum levels displayed substantial neutralisation capacity and IgG …

… CD4 and CD8 T cell frequencies. Broadly, these data indicate impaired GC-derived immunity
… a GC origin for certain humoral and memory B cell responses following mRNA vaccination. …

… of corticosteroids could impair this process. Even though memory T and B cells may start …
weeks of COVID-19 mRNA vaccination and their levels are significantly enhanced 2 to 4 weeks …

… use has minimal impact on circulating B cell, serum IgM, or … and bind to the intracellular
glucocorticoid receptor, creating a … 20 mg daily) had significantly decreased antibody response to …

… anergic B cells requires a functional Fas on the B cell and a … Immunosuppressive drugs such
as corticosteroids (prednisone … Notably, the main immunogenic part of the LDL particle is its …