Goat γδ T cell subpopulations defined by WC1 expression, responses to pathogens and cytokine production
AW Yirsaw, A Gillespie, E Britton, A Doerle… - Developmental & …, 2021 - Elsevier
The major functions of γδ T cells in mammals overlap with those of αβ T cells but differ in that
γδ T cells are rapid responders and see different types of antigens. While γδ T cells have
been shown to be a major population of circulating lymphocytes in artiodactyl species such
as cattle, sheep, and pigs, less is known about these cells in goats, an important agricultural
species. We have recently shown that WC1, a γδ T cell-specific family of hybrid pattern
recognition receptors/co-receptors, is a multigenic family in goats expanded beyond what …
γδ T cells are rapid responders and see different types of antigens. While γδ T cells have
been shown to be a major population of circulating lymphocytes in artiodactyl species such
as cattle, sheep, and pigs, less is known about these cells in goats, an important agricultural
species. We have recently shown that WC1, a γδ T cell-specific family of hybrid pattern
recognition receptors/co-receptors, is a multigenic family in goats expanded beyond what …
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