Gold nanoparticles modulate BCG-induced innate immune memory in human monocytes by shifting the memory response towards tolerance
Innate immune memory is characterized by a modulation in the magnitude with which innate
immune cells such as monocytes and macrophages respond to potential dangers,
subsequent to previous exposure to the same or unrelated agents. In this study, we have
examined the capacity of gold nanoparticles (AuNP), which are already in use for
therapeutic and diagnostic purposes, to modulate the innate memory induced by bacterial
agents. The induction of innate memory was achieved in vitro by exposing human primary …
immune cells such as monocytes and macrophages respond to potential dangers,
subsequent to previous exposure to the same or unrelated agents. In this study, we have
examined the capacity of gold nanoparticles (AuNP), which are already in use for
therapeutic and diagnostic purposes, to modulate the innate memory induced by bacterial
agents. The induction of innate memory was achieved in vitro by exposing human primary …
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