Gonadotropin suppression of apoptosis in cultured preovulatory follicles: mediatory role of endogenous insulin-like growth factor I
Although the majority of ovarian follicles undergo atresia through a mechanism involving
apoptotic cell death, in vivo studies concerning the hormonal regulation of atresia have been
difficult due to the presence of heterogeneous population of follicles in the ovary. In the
present study, the regulation of follicle apoptosis by gonadotropins, insulin-like growth factor
I (IGF-I), and IGF-binding protein 3 (IGFBP-3) was examined using a serum-free culture of
preovulatory follicles. Immature rats at 26 days of age received a single dose of PMSG. Two …
apoptotic cell death, in vivo studies concerning the hormonal regulation of atresia have been
difficult due to the presence of heterogeneous population of follicles in the ovary. In the
present study, the regulation of follicle apoptosis by gonadotropins, insulin-like growth factor
I (IGF-I), and IGF-binding protein 3 (IGFBP-3) was examined using a serum-free culture of
preovulatory follicles. Immature rats at 26 days of age received a single dose of PMSG. Two …
Gonadotropin suppression of apoptosis in cultured preovulatory follicles: mediatory role of endogenous insulin-like growth factor I.
The regulation of follicle apoptosis by gonadotropins, insulin-like growth factor I (IGF-I) and
IGF-binding protein 3 (IGFBP-3) was examined in rats using a serum-free culture of
preovulatory follicles. The results suggested that gonadotropins and IGF-I are survival
factors for ovarian follicles and that part of the suppressive action of gonadotropins is
mediated by endogenously produced IGF-I.
IGF-binding protein 3 (IGFBP-3) was examined in rats using a serum-free culture of
preovulatory follicles. The results suggested that gonadotropins and IGF-I are survival
factors for ovarian follicles and that part of the suppressive action of gonadotropins is
mediated by endogenously produced IGF-I.
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