Granulocyte colony-stimulating factor (GCSF) administration has been linked to the
development of monosomy 7 in severe congenital neutropenia and aplastic anemia. We
assessed the effect of pharmacologic doses of GCSF on monosomy 7 cells to determine
whether this chromosomal abnormality developed de novo or arose as a result of favored
expansion of a preexisting clone. Fluorescence in situ hybridization (FISH) of chromosome 7
was used to identify small populations of aneuploid cells. When bone marrow mononuclear …

Granulocyte colony-stimulating factor preferentially stimulates proliferation of monosomy 7
cells bearing the isoform IV receptor | CiNii Research … Granulocyte colony-stimulating factor
preferentially stimulates proliferation of monosomy 7 cells bearing the isoform IV receptor …