Graves' disease (GD) is the most common cause of hyperthyroidism in developed Countries.
It is more common between 30 and 60 years; 5–10 times more frequent in women. The
genetic predisposition accounts for 79% of the risk for GD, while environmental factors for
21%. About 70% of genes associated with autoimmune thyroid disorders (AITD) are
implicated in T-cell function. Among GD endogenous factors, estrogens, X-inactivation and
microchimerism are important. Among environmental risk factors, smoking, iodine excess …