Green synthesis of multimodal 'OFF–ON'activatable MRI/optical probes

J Gallo, N Vasimalai, MT Fernandez-Arguelles… - Dalton …, 2016 - pubs.rsc.org
Dalton Transactions, 2016pubs.rsc.org
Diagnosis by MRI is frequently non-trivial due to the low sensitivity of the technique. Signal
enhancing contrast agents (CAs) are used to aid in the analysis of MR images. We present
here a simple protocol for the preparation of responsive CAs based on Mn nanosheets. Mn
nanostructures presented here undergo a chemical and structural change in the presence of
altered physiological conditions that activate their signal. This strategy allows for a reduction
of background, increasing the sensitivity of the technique. The simple synthetic protocol …
Diagnosis by MRI is frequently non-trivial due to the low sensitivity of the technique. Signal enhancing contrast agents (CAs) are used to aid in the analysis of MR images. We present here a simple protocol for the preparation of responsive CAs based on Mn nanosheets. Mn nanostructures presented here undergo a chemical and structural change in the presence of altered physiological conditions that activate their signal. This strategy allows for a reduction of background, increasing the sensitivity of the technique. The simple synthetic protocol followed allows for the combination of the nanosheets with reporter molecules for other imaging techniques, like carbon quantum dots for optical imaging.
The Royal Society of Chemistry
以上显示的是最相近的搜索结果。 查看全部搜索结果