Gut microbiota is critical for the induction of chemotherapy-induced pain
Nature neuroscience, 2017•nature.com
Chemotherapy-induced pain is a dose-limiting condition that affects 30% of patients
undergoing chemotherapy. We found that gut microbiota promotes the development of
chemotherapy-induced mechanical hyperalgesia. Oxaliplatin-induced mechanical
hyperalgesia was reduced in germ-free mice and in mice pretreated with antibiotics.
Restoring the microbiota of germ-free mice abrogated this protection. These effects appear
to be mediated, in part, by TLR4 expressed on hematopoietic cells, including macrophages.
undergoing chemotherapy. We found that gut microbiota promotes the development of
chemotherapy-induced mechanical hyperalgesia. Oxaliplatin-induced mechanical
hyperalgesia was reduced in germ-free mice and in mice pretreated with antibiotics.
Restoring the microbiota of germ-free mice abrogated this protection. These effects appear
to be mediated, in part, by TLR4 expressed on hematopoietic cells, including macrophages.
Abstract
Chemotherapy-induced pain is a dose-limiting condition that affects 30% of patients undergoing chemotherapy. We found that gut microbiota promotes the development of chemotherapy-induced mechanical hyperalgesia. Oxaliplatin-induced mechanical hyperalgesia was reduced in germ-free mice and in mice pretreated with antibiotics. Restoring the microbiota of germ-free mice abrogated this protection. These effects appear to be mediated, in part, by TLR4 expressed on hematopoietic cells, including macrophages.
nature.com
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