Gut to lung translocation and antibiotic mediated selection shape the dynamics of Pseudomonas aeruginosa in an ICU patient

RM Wheatley, JD Caballero, TE van der Schalk… - Nature …, 2022 - nature.com
… between sites in the human body, but the dynamics and … Here we investigate the link between
gut and lung Pseudomonaslung colonization in the ICU was driven by the translocation

Assessing the contribution of gut-to-lung translocation to bacterial colonization and antibiotic resistance in an ICU patient

RM Wheatley, JD Caballero, TE van der Schalk… - medRxiv, 2022 - medrxiv.org
… but the dynamics and consequences of within-host translocation remain poorly understood.
Here we investigate the link between gut and lung Pseudomonas … inflammation mediated by …

Cystic fibrosis lung environment and Pseudomonas aeruginosa infection

AY Bhagirath, Y Li, D Somayajula, M Dadashi… - BMC pulmonary …, 2016 - Springer
… CFTRs are expressed in many organs such as the kidneys, pancreas, intestine, heart, vas
deferens and lungs [9]. CFTRs have been shown to perform a significant role in regulation of …

Evolutionary pathways and trajectories in antibiotic resistance

F Baquero, JL Martinez, V F. Lanza… - Clinical Microbiology …, 2021 - Am Soc Microbiol
dynamics, modeling and designing interventions. Studies on … complement directional
evolution mediated by successive … of an antibiotic, as in the case of Pseudomonas aeruginosa …

Antibiotic resistance alters the ability of Pseudomonas aeruginosa to invade bacteria from the respiratory microbiome

S Lindon, S Shah, DR Gifford, C Lood… - Evolution …, 2024 - academic.oup.com
… Here we investigate how antibiotic resistance impacts the ability of … bacterial pathogen
Pseudomonas aeruginosa and the respiratory … could mediate this interaction with S. epidermidis. …

Mechanisms and Targeted Therapies for Pseudomonas aeruginosa Lung Infection

CS Curran, T Bolig, P Torabi-Parizi - American journal of respiratory …, 2018 - atsjournals.org
… Other molecules involved in the needle complex, translocation apparatus, or associated …
to the oxidative effects of QS-mediated release of pyocyanin in the murine lung (169). These …

Intrahost evolution of the gut microbiota

HC Barreto, I Gordo - Nature Reviews Microbiology, 2023 - nature.com
Pseudomonas aeruginosa evolution in individuals with cystic fibrosis 64 . Such mutators can
be maintained in the lungs … strain evolving translocation and reveal which gut adaptive traits …

Pseudomonas aeruginosa population dynamics in a vancomycin-induced murine model of gastrointestinal carriage

M Lebrun-Corbin, BH Cheung, K Hullahalli, K Dailey… - …, 2024 - pmc.ncbi.nlm.nih.gov
… dissemination from the gut to the gallbladder, spleen, liver, or lungs occasionally occurs…
Gut to lung translocation and antibiotic mediated selection shape the dynamics of Pseudomonas

Ecological and evolutionary mechanisms driving within-patient emergence of antimicrobial resistance

MJ Shepherd, T Fu, NE Harrington, A Kottara… - Nature Reviews …, 2024 - nature.com
… and mutation of the Pseudomonas-derived cephalosporinase (… This ecological process, also
referred to as strain translocation … aeruginosa strain from the gut to the lung was followed by …

Bacteriophage-antibiotic combination therapy against extensively drug-resistant Pseudomonas aeruginosa infection to allow liver transplantation in a toddler

B Van Nieuwenhuyse, D Van der Linden… - Nature …, 2022 - nature.com
… well tolerated, without antibody-mediated phage neutralization. It … aeruginosa translocations
from liver abscesses to the … patient with Mycobacterium abscessus lung infection was treated …