[HTML][HTML] H2O2 treatment or serum deprivation induces autophagy and apoptosis in naked mole-rat skin fibroblasts by inhibiting the PI3K/Akt signaling pathway

S Zhao, L Li, S Wang, C Yu, B Xiao, L Lin, W Cong… - Oncotarget, 2016 - ncbi.nlm.nih.gov
… demonstrated that serum starvation and H 2 O 2 treatment induced autophagy in NMR skin
fibroblasts, which is in agreement with previous studies suggesting that autophagy may be …

[PDF][PDF] Atg5 plays crucial roles in naked mole-rat cell

J Kim - 2020 - ir.library.osaka-u.ac.jp
… did not affect the autophagy-related phenotypes induced by Atg5 … autophagy as a critical
regulatory mechanism for apoptosis … fibroblasts and Naked mole-rat skin fibroblasts. Cells were …

Senescent cell death as an aging resistance mechanism in naked mole-rat

Y Kawamura, K Oka, M Takamori, Y Sugiura, Y Oiwa… - BioRxiv, 2020 - biorxiv.org
… Generally, accumulation of lipid peroxide associates with ferroptosis 48 . However, in … H
2 O 2 treatment or serum deprivation induces autophagy and apoptosis in naked mole-rat skin

Stress resistance in the naked mole-rat: the bare essentials–a mini-review

KN Lewis, J Mele, PJ Hornsby, R Buffenstein - Gerontology, 2012 - karger.com
… Our new data reveal that naked mole-rat fibroblasts stop … studied to date, naked mole-rat
skin fibroblasts display marked … including diquat and hydrogen peroxide, but extends to heavy …

[HTML][HTML] Levels of Leydig cell autophagy regulate the fertility of male naked mole-rats

W Yang, L Li, X Huang, G Kan, L Lin, J Cheng, C Xu… - Oncotarget, 2017 - ncbi.nlm.nih.gov
… The naked mole-rat (Heterocephalus glaber; NMR) is a highly eusocial rodent that
inhabits East Africa. Colonies often consist of 40–80 individuals and may contain up to 300 …

Probing the protein homeostasis mechanisms in long-lived naked mole-rats

Z Du - 2021 - repository.cam.ac.uk
… The naked mole-rat (NMR) is a fascinating animal which has … Induction of autophagy by
rapamycin in the NMR skin … , whose hypoxic habitation facilitate H2O2 production, accumulate …

Learning of nature: The curious case of the naked mole rat

FA Lagunas-Rangel, V Chávez-Valencia - Mechanisms of Ageing and …, 2017 - Elsevier
Autophagy has been demonstrated to be another important … Therefore, these results indicate
that naked mole-rat cells … -HA facilitates elasticity of the skin, which is a useful condition for …

The use of non-traditional models in the study of cancer resistance—the case of the naked mole rat

A Shepard, JL Kissil - Oncogene, 2020 - nature.com
… models is the naked mole rat (Heterocephalus glaber). … either induction or inhibition of
autophagy in NMRs induced … of hydrogen peroxide and more readily undergo apoptosis, when …

Walking the oxidative stress tightrope: a perspective from the naked mole-rat, the longest-living rodent

KA Rodriguez, E Wywial, VI Perez… - Current …, 2011 - ingentaconnect.com
… lived rodent, the naked mole-rat, which maintains good health … the main cellular scavenger
of hydrogen peroxide (H2O2) [29]. … Furthermore, mice lacking SOD1 have an increased risk of …

Mitochondria: Hubs of hypoxia-tolerance in naked mole-rats

H Cheng - 2023 - ruor.uottawa.ca
… -specific fashion to minimize the O2 consumption and hypoxia-inducedapoptosis inducing
factor AKT … ) activity is enhanced by tyrosine kinase Lck phosphorylation due to H2O2 (a …