HDL-associated enzymes and proteins in hemodialysis patients
LD Cacciagiú, AI González, LG Rosso, T Meroño… - Clinical …, 2012 - Elsevier
LD Cacciagiú, AI González, LG Rosso, T Meroño, G De Marziani, A Elbert, G Berg, F Brites…
Clinical biochemistry, 2012•ElsevierOBJECTIVES: To evaluate HDL-associated proteins and enzymes and their relation with
lipoprotein profile and inflammatory markers in chronic renal patients on hemodialysis.
DESIGN AND METHODS: We studied 53 patients under hemodialysis and 32 healthy
subjects as controls. We compared plasma lipids, Apoprotein-AI and hs-CRP, as a marker of
chronic inflammation. We evaluated proteins and enzymes associated to HDL, involved in
several points of lipoprotein metabolism: CETP, paraoxonase and LpPLA2 activities …
lipoprotein profile and inflammatory markers in chronic renal patients on hemodialysis.
DESIGN AND METHODS: We studied 53 patients under hemodialysis and 32 healthy
subjects as controls. We compared plasma lipids, Apoprotein-AI and hs-CRP, as a marker of
chronic inflammation. We evaluated proteins and enzymes associated to HDL, involved in
several points of lipoprotein metabolism: CETP, paraoxonase and LpPLA2 activities …
OBJECTIVES
To evaluate HDL-associated proteins and enzymes and their relation with lipoprotein profile and inflammatory markers in chronic renal patients on hemodialysis.
DESIGN AND METHODS
We studied 53 patients under hemodialysis and 32 healthy subjects as controls. We compared plasma lipids, Apoprotein-AI and hs-CRP, as a marker of chronic inflammation. We evaluated proteins and enzymes associated to HDL, involved in several points of lipoprotein metabolism: CETP, paraoxonase and LpPLA2 activities. Hepatic lipase was measured in postheparin plasma.
RESULTS
Patients showed higher triglycerides and lower LDL-, HDL- and total-cholesterol than controls (p<0.05). Also, in comparison with controls, Apoprotein-AI, paraoxonase and hepatic lipase were lower, while CETP was higher (p<0.03). LpPLA2 did not show changes between groups.
CONCLUSION
Beyond plasma lipid-lipoprotein profile, other factors could contribute to induce a pro-oxidative and pro-inflammatory status. The protective role of HDL does not only depend on its concentration, but also on its functionality.
Elsevier
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