… target for tumour radiosensitisation. Here, … HIF-1 blockade with radiotherapy. In doing so,
we describe clinical scenarios in which HIF-1 inhibition might optimise tumour radiosensitivity. …

… Although this study focused on the involvement of HIF-1 in determining tumor radiosensitivity,
the findings may apply to other treatment modalities. As mentioned above, reoxygenation …

… the tumor vasculature. The impact that HIF-1 activation has on overall tumor radiosensitivity,
… We reveal here that HIF-1 plays an important role in determining tumor radioresponsiveness …

… affected by the radiation sensitivity status of non-small-cell lung cancers. Inhibition of VEGFR2
contributed to upregulation of HIF-1α expression, which improved radiation sensitivity by …

… how the HIF-1 pathway impacts on radioresistance of solid tumors, with special focus on
HIF-1–induced changes in tumor … Apart from the radiosensitivity of tumor cells as an important …

… tumor progression and poor patient outcome [19,23]. In the present study, we investigated
the role of HIF-1/2α on radiation sensitivity … of NSCLC with intact or deleted HIF-1/2α proteins. …

… HIF-1α affects chemo-/radiosensitivity via regulation of genes related to metabolic pathways…
targeted therapeutics is of great significance for improving chemo-/radiosensitivity in tumors. …

… in tumours with admixes of HIF-1 proficient to HIF-1 deficient cells … uncouple the tumour
growth promoting effects of HIF-1 and … increases the radiation sensitivity of hypoxic cells. In solid …

… biological radioresistance in cancer cells under hypoxic conditions; therefore, HIF-1 has been
… Although cells are more radiosensitive at the late G 1 and early S phases than at the late S …

… -1 (HIF-1) overexpression has been linked to tumor … of HIF-1 using chetomin, a disrupter of
the interaction of HIF-1 with the transcriptional coactivator p300, influences the radiosensitivity …