HIV-1 competition experiments in humanized mice show that APOBEC3H imposes selective pressure and promotes virus adaptation
Y Nakano, N Misawa, G Juarez-Fernandez… - PLoS …, 2017 - journals.plos.org
APOBEC3 (A3) family proteins are DNA cytosine deaminases recognized for contributing to
HIV-1 restriction and mutation. Prior studies have demonstrated that A3D, A3F, and A3G
enzymes elicit a robust anti-HIV-1 effect in cell cultures and in humanized mouse models.
Human A3H is polymorphic and can be categorized into three phenotypes: stable,
intermediate, and unstable. However, the anti-viral effect of endogenous A3H in vivo has yet
to be examined. Here we utilize a hematopoietic stem cell-transplanted humanized mouse …
HIV-1 restriction and mutation. Prior studies have demonstrated that A3D, A3F, and A3G
enzymes elicit a robust anti-HIV-1 effect in cell cultures and in humanized mouse models.
Human A3H is polymorphic and can be categorized into three phenotypes: stable,
intermediate, and unstable. However, the anti-viral effect of endogenous A3H in vivo has yet
to be examined. Here we utilize a hematopoietic stem cell-transplanted humanized mouse …
Correction: HIV-1 competition experiments in humanized mice show that APOBEC3H imposes selective pressure and promotes virus adaptation
Y Nakano, N Misawa, G Juarez-Fernandez… - PLoS …, 2017 - journals.plos.org
1. Nakano Y, Misawa N, Juarez-Fernandez G, Moriwaki M, Nakaoka S, Funo T, et al.(2017)
HIV-1 competition experiments in humanized mice show that APOBEC3H imposes selective
pressure and promotes virus adaptation. PLoS Pathog 13 (5): e1006348. https://doi.
org/10.1371/journal. ppat. 1006348 PMID: 28475648
HIV-1 competition experiments in humanized mice show that APOBEC3H imposes selective
pressure and promotes virus adaptation. PLoS Pathog 13 (5): e1006348. https://doi.
org/10.1371/journal. ppat. 1006348 PMID: 28475648
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