HMGB1-induced ILC2s activate dendritic cells by producing IL-9 in asthmatic mouse model
Asthma is a disease of the respiratory system that is commonly considered a T-helper 2
(Th2) cell-associated inflammatory disease. Group 2 innate lymphoid cells (ILC2s) promote
the inflammatory responses in asthma by secreting type 2 cytokines. Interleukin (IL)-9 also
serves as a promoting factor in asthma and it is well known that ILC2s have an autocrine
effect of IL-9 to sustain their survival and proliferation. However, the specific role of ILC2-
derived IL-9 in asthma remains unclear. HMGB1 (High-Mobility Group Box-1) is a nuclear …
(Th2) cell-associated inflammatory disease. Group 2 innate lymphoid cells (ILC2s) promote
the inflammatory responses in asthma by secreting type 2 cytokines. Interleukin (IL)-9 also
serves as a promoting factor in asthma and it is well known that ILC2s have an autocrine
effect of IL-9 to sustain their survival and proliferation. However, the specific role of ILC2-
derived IL-9 in asthma remains unclear. HMGB1 (High-Mobility Group Box-1) is a nuclear …
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