The effect of feeding graded levels of boiled sorrel seed meal (BSSM) at 0, 15, 30, 45 and 60% as replacement for groundnut cake in the diet of 200 seven day old chicks of Isa brown x Goldline cockerel on heamatological and serum biochemical indices was assessed in a 14week feeding trial. Each treatment consisted of forty birds and was replicated four times with 10 birds per replicate in a completely randomized design. At the end of the experiment, blood samples were randomly collected from four birds in each group for heamatological and blood chemistry studies. BSSM at 60% significantly (P< 0.05) increased the values of RBC, Hb, WBC, PCV and MCV although they were within normal ranges. Total protein and albumin were significantly (P< 0.05) increased while creatinine was significantly (P< 0.05) reduced by higher levels of BSSM in the diet. It was concluded that up to 60% of GNC can be replaced by BSSM in the diet of cockerels without adverse effects on blood characteristics.