Abstract Heart Rate Variability (HRV) refers to the beat-to-beat variation in intervals in
heartbeat within the electrocardiogram. In this paper, we review the possible usefulness of
HRV as a translational and transdiagnostic biomarker. After a brief introduction on the
relevance of novel translational biomarkers, we focus our attention on HRV and its
relationship with emotional and cognitive deficits. This discussion is followed by a
description of the many ways in which HRV can be quantified, paying attention to both the …