As one of the greatest threats facing the 21st century, antibiotic resistance is now a major
public health concern. Host-defense peptides (HDPs) offer an alternative approach to
combat emerging multi-drug-resistant bacteria. It is known that helical HDPs such as
magainin 2 and its analogs adopt cationic amphipathic conformations upon interaction with
bacterial membranes, leading to membrane disruption and subsequent bacterial cell death.
We have previously shown that amphipathic sulfono-γ-AApeptides could mimic magainin 2 …