Hemoglobin degrading proteases of Plasmodium falciparum as antimalarial drug targets
T Qidwai - Current drug targets, 2015 - ingentaconnect.com
Current drug targets, 2015•ingentaconnect.com
Plasmepsins, falcipains and aminopeptidases are Plasmodium falciparum proteases
involved in human host hemoglobin degradation and other processes like erythrocyte
invasion and rupture. Antimalarial drug resistance and natural selection in parasite are
important reasons that create the urgent need of novel targets and lead compounds to
overcome the burden of malaria. This report explored progress of the study covering
proteases and their inhibitors specific to hemoglobin degradation. Additionally, in silico …
involved in human host hemoglobin degradation and other processes like erythrocyte
invasion and rupture. Antimalarial drug resistance and natural selection in parasite are
important reasons that create the urgent need of novel targets and lead compounds to
overcome the burden of malaria. This report explored progress of the study covering
proteases and their inhibitors specific to hemoglobin degradation. Additionally, in silico …
Plasmepsins, falcipains and aminopeptidases are Plasmodium falciparum proteases involved in human host hemoglobin degradation and other processes like erythrocyte invasion and rupture. Antimalarial drug resistance and natural selection in parasite are important reasons that create the urgent need of novel targets and lead compounds to overcome the burden of malaria. This report explored progress of the study covering proteases and their inhibitors specific to hemoglobin degradation. Additionally, in silico predicted antimalarial targets, balancing selection and drug-protein interaction are included.
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