[HTML][HTML] Hepatic DsbA-L protects mice from diet-induced hepatosteatosis and insulin resistance
Hepatic insulin resistance and hepatosteatosis in diet-induced obesity are associated with
various metabolic diseases, yet the underlying mechanisms remain to be fully elucidated.
Here we show that the expression levels of the disulfide-bond A oxidoreductase-like protein
(DsbA-L) are significantly reduced in the liver of obese mice and humans. Liver-specific
knockout or adenovirus-mediated overexpression of DsbA-L exacerbates or alleviates,
respectively, high-fat diet–induced mitochondrial dysfunction, hepatosteatosis, and insulin …
various metabolic diseases, yet the underlying mechanisms remain to be fully elucidated.
Here we show that the expression levels of the disulfide-bond A oxidoreductase-like protein
(DsbA-L) are significantly reduced in the liver of obese mice and humans. Liver-specific
knockout or adenovirus-mediated overexpression of DsbA-L exacerbates or alleviates,
respectively, high-fat diet–induced mitochondrial dysfunction, hepatosteatosis, and insulin …
Hepatic DsbA-L protects mice from diet-induced hepatosteatosis and insulin resistance.
CHZ Chen HongZhi, BJL Bai JuLi, DF Dong Feng… - 2017 - cabidigitallibrary.org
Hepatic insulin resistance and hepatosteatosis in diet-induced obesity are associated with
various metabolic diseases, yet the underlying mechanisms remain to be fully elucidated.
Here we show that the expression levels of the disulfide-bond A oxidoreductase-like protein
(DsbA-L) are significantly reduced in the liver of obese mice and humans. Liver-specific
knockout or adenovirus-mediated overexpression of DsbA-L exacerbates or alleviates,
respectively, high-fat diet-induced mitochondrial dysfunction, hepatosteatosis, and insulin …
various metabolic diseases, yet the underlying mechanisms remain to be fully elucidated.
Here we show that the expression levels of the disulfide-bond A oxidoreductase-like protein
(DsbA-L) are significantly reduced in the liver of obese mice and humans. Liver-specific
knockout or adenovirus-mediated overexpression of DsbA-L exacerbates or alleviates,
respectively, high-fat diet-induced mitochondrial dysfunction, hepatosteatosis, and insulin …
以上显示的是最相近的搜索结果。 查看全部搜索结果