Hepatic cirrhosis caused by low-dose oral amiodarone therapy
SR Puli, MA Fraley, V Puli, AB Kuperman… - The American journal of …, 2005 - Elsevier
A 63-year-old man presented with ascites after therapy with amiodarone, 200 mg orally once
per day for 22.5 months. A liver biopsy showed grade 3 chronic hepatitis and micronodular
cirrhosis. The presence of striking microvesicular steatosis on light microscopy and
lysosomal inclusion bodies on electron microscopy suggested amiodarone hepatotoxicity.
This is the first reported case of amiodarone-induced hepatic cirrhosis associated with
chronic treatment with 200 mg orally once per day for less than 2 years.
per day for 22.5 months. A liver biopsy showed grade 3 chronic hepatitis and micronodular
cirrhosis. The presence of striking microvesicular steatosis on light microscopy and
lysosomal inclusion bodies on electron microscopy suggested amiodarone hepatotoxicity.
This is the first reported case of amiodarone-induced hepatic cirrhosis associated with
chronic treatment with 200 mg orally once per day for less than 2 years.
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