Hepatic differentiation of human embryonic stem cells by coupling substrate stiffness and microtopography
C Luo, D Lü, L Zheng, F Zhang, X Zhang, S Lü… - Biomaterials …, 2021 - pubs.rsc.org
Mechanical or physical cues are associated with the growth and differentiation of embryonic
stem cells (ESCs). While the substrate stiffness or topography independently affects the
differentiation of ESCs, their cooperative regulation on lineage-specific differentiation
remains largely unknown. Here, four topographical configurations on stiff or soft
polyacrylamide hydrogel were combined to direct hepatic differentiation of human H1 cells
via a four-stage protocol, and the coupled impacts of stiffness and topography were …
stem cells (ESCs). While the substrate stiffness or topography independently affects the
differentiation of ESCs, their cooperative regulation on lineage-specific differentiation
remains largely unknown. Here, four topographical configurations on stiff or soft
polyacrylamide hydrogel were combined to direct hepatic differentiation of human H1 cells
via a four-stage protocol, and the coupled impacts of stiffness and topography were …
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