Hepatic retinol metabolism. Distribution of retinoids, enzymes, and binding proteins in isolated rat liver cells.
R Blomhoff, M Rasmussen, A Nilsson… - Journal of Biological …, 1985 - ASBMB
The main retinoids and some binding proteins and enzymes involved in retinol metabolism
have been quantified in different types of rat liver cells. Hepatic perisinusoidal stellate cells
contained 28-34 nmol of retinoids/10 (6) cells, and parenchymal liver cells contained 0.5-0.8
nmol of retinoids/10 (6) cells, suggesting that as much as 80% of more of total liver retinoids
might be stored in stellate cells with the rest stored in parenchymal cells. Isolated endothelial
cells and Kupffer cells contained very low levels of retinoids. More than 98% of the retinoids …
have been quantified in different types of rat liver cells. Hepatic perisinusoidal stellate cells
contained 28-34 nmol of retinoids/10 (6) cells, and parenchymal liver cells contained 0.5-0.8
nmol of retinoids/10 (6) cells, suggesting that as much as 80% of more of total liver retinoids
might be stored in stellate cells with the rest stored in parenchymal cells. Isolated endothelial
cells and Kupffer cells contained very low levels of retinoids. More than 98% of the retinoids …
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