The high-pressure single pulse shock tube (HPST) at the University of Illinois at Chicago has been used to study the oxidation of toluene at reflected shock pressures from 22 to 550 bar and temperatures from 1210 to 1480 K. Experiments were performed for dilute stoichiometric, Φ=1, and rich, Φ=5, reagent mixtures. Stable species were analyzed using gas chromatography and gas chromatography/mass spectrometry. The resulting data set is the first that provides species concentrations over such extremes of pressure, temperature, and stoichiometry, and it serves as an excellent base for the validation and refinement of future detailed chemical kinetic models. Two literature models for the oxidation of toluene that have been validated against atmospheric pressure turbulent flow reactor and jet stirred reactor data were used to simulate the experimental data. Several modifications were made to one model to more accurately simulate the high-pressure/high-temperature experimental data. The modified model reproduces the Φ=1 experimental data well and forms the first step in the development of a more comprehensive model for toluene combustion validated over wide ranges of temperature and pressure.