Higher levels of pro-inflammatory cytokines are associated with higher levels of glutamate in the anterior cingulate cortex in depressed adolescents
Animal models of stress and related conditions, including depression, have shown that
elevated peripheral levels of inflammatory cytokines have downstream consequences on
glutamate (Glu) in the brain. Although studies in human adults with depression have
reported evidence of higher inflammation but lower Glu in the anterior cingulate cortex
(ACC), the extent to which peripheral inflammation contributes to glutamatergic
abnormalities in adolescents with depression is not well-understood. It is also unclear …
elevated peripheral levels of inflammatory cytokines have downstream consequences on
glutamate (Glu) in the brain. Although studies in human adults with depression have
reported evidence of higher inflammation but lower Glu in the anterior cingulate cortex
(ACC), the extent to which peripheral inflammation contributes to glutamatergic
abnormalities in adolescents with depression is not well-understood. It is also unclear …
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