Highly efficient metal-free one-pot synthesis of α-aminophosphonates through reduction followed by Kabachnik–fields reaction using three-component system
MK Kolli, P Elamathi, G Chandrasekar… - Synthetic …, 2018 - Taylor & Francis
MK Kolli, P Elamathi, G Chandrasekar, VR Katta, G Balvantsinh Raolji
Synthetic Communications, 2018•Taylor & FrancisOne-pot synthesis of α-aminophosphonates directly from aryl nitro compounds,
aldehydes/ketones, and diethyl phosphite using sodium dithionite through reduction and
followed by Kabachnik–Fields reaction under metal-free conditions is reported. The major
advantages are excellent yield, high chemoselectivity, neutral reaction medium, and simple
experimental procedure. This methodology consists of the following steps: 1) amine
formation from nitro compound, 2) imine formation from amine and aldehyde/ketone, 3) …
aldehydes/ketones, and diethyl phosphite using sodium dithionite through reduction and
followed by Kabachnik–Fields reaction under metal-free conditions is reported. The major
advantages are excellent yield, high chemoselectivity, neutral reaction medium, and simple
experimental procedure. This methodology consists of the following steps: 1) amine
formation from nitro compound, 2) imine formation from amine and aldehyde/ketone, 3) …
Abstract
One-pot synthesis of α-aminophosphonates directly from aryl nitro compounds, aldehydes/ketones, and diethyl phosphite using sodium dithionite through reduction and followed by Kabachnik–Fields reaction under metal-free conditions is reported. The major advantages are excellent yield, high chemoselectivity, neutral reaction medium, and simple experimental procedure. This methodology consists of the following steps: 1) amine formation from nitro compound, 2) imine formation from amine and aldehyde/ketone, 3) phosphate addition to imine.
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