[PDF][PDF] Histo-morphometric demonstration of cardiotoxic effects of aspartame on mice
DR Gudadhe, SS Talhar, P Bokariya, MR Shende… - Iosr J …, 2013 - researchgate.net
Iosr J Pharm, 2013•researchgate.net
Aim & Objectives: To demonstrate microscopic structural alterations, if any, in myocardium of
adult Swiss albino mice as an irreversible effect of neonatal exposure of Aspartame. Material
& Methods: Study was conducted on Swiss albino mice grouped into 25 control and 25
experimental. Aspartame was injected intraperitoneally in experimental group of neonatal
mice at a dose of 100 µg/g body weight per day for two weeks while age matched control
group of mice received same volume of normal saline intraperitoneally. Mice of both the …
adult Swiss albino mice as an irreversible effect of neonatal exposure of Aspartame. Material
& Methods: Study was conducted on Swiss albino mice grouped into 25 control and 25
experimental. Aspartame was injected intraperitoneally in experimental group of neonatal
mice at a dose of 100 µg/g body weight per day for two weeks while age matched control
group of mice received same volume of normal saline intraperitoneally. Mice of both the …
Abstract
Aim & Objectives: To demonstrate microscopic structural alterations, if any, in myocardium of adult Swiss albino mice as an irreversible effect of neonatal exposure of Aspartame.
Material & Methods: Study was conducted on Swiss albino mice grouped into 25 control and 25 experimental. Aspartame was injected intraperitoneally in experimental group of neonatal mice at a dose of 100 µg/g body weight per day for two weeks while age matched control group of mice received same volume of normal saline intraperitoneally. Mice of both the groups were sacrificed by euthanasia at 60 days of age or above. Observations of weight of heart as well as histo-morphometry of diameter of cardiac myocyte were recorded.
Results: There was significant increase in the weight of heart and diameter of cardiac myocytes in experimental group. However the number of cardiac myocytes was apparently reduced in experimental group with a corresponding increase in ground material of myocardial stroma.
Conclusion: Our observations suggest residual micro structural changes in myocardium of adult mice in the form of compensatory hypertrophy of myocytes as a remote toxic effect of Aspartame probably resulting from myocardial damage during dosing period of Aspartame in neonatal mice. Thus the changes are irreversible and compensatory but not fatal, that may be compromising with life.
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