[HTML][HTML] Histone deacetylase 2 is required for chromatin condensation and subsequent enucleation of cultured mouse fetal erythroblasts
P Ji, V Yeh, T Ramirez, M Murata-Hori, HF Lodish - Haematologica, 2010 - ncbi.nlm.nih.gov
P Ji, V Yeh, T Ramirez, M Murata-Hori, HF Lodish
Haematologica, 2010•ncbi.nlm.nih.govBackground During the final stages of differentiation of mammalian erythroid cells, the
chromatin is condensed and enucleated. We previously reported that Rac GTPases and
their downstream target, mammalian homolog of Drosophila diaphanous 2 (mDia2), are
required for enucleation of in vitro cultured mouse fetal liver erythroblasts. However, it is not
clear how chromatin condensation is achieved and whether it is required for enucleation.
chromatin is condensed and enucleated. We previously reported that Rac GTPases and
their downstream target, mammalian homolog of Drosophila diaphanous 2 (mDia2), are
required for enucleation of in vitro cultured mouse fetal liver erythroblasts. However, it is not
clear how chromatin condensation is achieved and whether it is required for enucleation.
Abstract
Background
During the final stages of differentiation of mammalian erythroid cells, the chromatin is condensed and enucleated. We previously reported that Rac GTPases and their downstream target, mammalian homolog of Drosophila diaphanous 2 (mDia2), are required for enucleation of in vitro cultured mouse fetal liver erythroblasts. However, it is not clear how chromatin condensation is achieved and whether it is required for enucleation.
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